PReS-FINAL-2017: Systemic onset juvenile idiopathic arthritis (SOJIA)-a 5-year survey in a pediatric rheumatology department
نویسندگان
چکیده
Introduction Systemic onset Juvenile Idiopathic Arthritis (SoJIA) is rare pediatric disease, it accounts for 10% of children with Juvenile Idiopathic Arthritis. The onset of disese can be vary nonspecific and may suggest bacterial or viral infection, malignancy or other rheumatic disease. It is highly characterised by its extra-articular systemic illness features and, in some ways, it resembles a fever of unknown origin. Diagnosis is mostly clinical by using ILAR criteria (International League of Associations for Rheumatology).
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Background: Systemic-onset Juvenile Idiopathic Arthritis (SoJIA) is an autoinflammatory disease with complex genetic trait starts in children less than 16 years of age with fever and cutaneous rash. Despite, the main genetic factors that may play a role in SoJIA have not yet been identified. High level of interleukin-1beta in the blood of SoJIA patients has been reported. The production and sec...
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Systemic-onset juvenile idiopathic arthritis (SoJIA) is a form of juvenile idiopathic arthritis (JIA) that typically presents with prominent systemic features and accounts for approximately 10-15% of children with JIA. Pro-inflammatory cytokine pathways are thought to be involved in its pathogenesis, including interleukin-1 (IL-1) and interleukin-6 (IL-6), and laboratory tests demonstrate a pro...
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Methods We included patients from a prospective diagnostic test trial called: levels of total and glycosilated ferritin in children with systemic onset juvenile idiopathic arthritis (SoJIA) and children with other causes of FUO. Patients had been referred with the diagnosis of FUO, defined as: temperature of >38.3°C at least twice per week during two or more weeks and without a clear diagnosis ...
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